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DRUG METABOLIZING ENZYMES: CYTOCHROME P450 AND OTHER ENZYMES IN DRUG DISCOVERY AND DEVELOPMENT
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Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P45 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P45 and similar enzymes – as well as parallel issues shaping the pharmaceutical industry – to promote the next generation of safer, more effective drugs.
Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P45 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P45 and similar enzymes – as well as parallel issues shaping the pharmaceutical industry – to promote the next generation of safer, more effective drugs.
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